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Your Santa Cruz Vacation

With one of our vacation packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the program during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz vacation is just clicks away with Expedia.

The Latest Santa Cruz vacation packages

Price found within the past 48 hours. Click for updated prices.
Novotel Santa Cruz De La Sierra
Swissôtel Santa Cruz De La Sierra
Hotel Cortez
Camino Real Hotel
Yotau All Suites Hotel
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Discover the most popular places to visit in Santa Cruz

What to do in Santa Cruz

Santa Cruz Hotel Deals

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
$43 nightly
The price is $43 total per night from Jan 17 to Jan 18
$43 total
Jan 17 - Jan 18
9.4/10 Exceptional! (80 reviews)
Amazing breakfast

Reviewed on Jan 7, 2026

Ibis Santa Cruz DE LA Sierra
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
$98 nightly
The price is $98 total per night from Feb 11 to Feb 12
$98 total
Feb 11 - Feb 12
9/10 Wonderful! (213 reviews)
Muy bien exelente

Reviewed on Dec 9, 2025

Marriott Santa Cruz de la Sierra Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
$131 nightly
The price is $131 total per night from Feb 6 to Feb 7
$131 total
Feb 6 - Feb 7
8.8/10 Excellent! (349 reviews)
everything

Reviewed on Jan 6, 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Cruz Vacation Packages

Things to do in Santa Cruz

Santa Cruz offers a vibrant mix of city-themed and cultural experiences perfect for families. Visitors can explore shopping centers and malls, unwind at resorts, and enjoy outdoor adventures like hiking and standup paddleboarding. For those looking for leisure, there's plenty of window shopping and long strolls to enjoy. Thrill-seekers can also find exciting roller coasters to experience, making Santa Cruz a well-rounded destination for all types of tourists.

Shopping

In Santa Cruz, visit Ventura Mall for a vibrant shopping experience with entertainment and family-friendly vibes. La Recova Artisan Walk offers a unique market atmosphere perfect for local crafts. If you're up for a drive, check out Patio Design LifeStyle Center for a stylish shopping environment.

Recreation

Experience the vibrant atmosphere at Ramon Tahuichi Aguilera Stadium, where you can enjoy local sports events. For a family-friendly outing, catch a movie at Cine Center. Don't miss the cultural richness at Casa Municipal de Cultura Raúl Otero Reiche, featuring captivating performances and artistic events.

Adventure

Parque Nacional Amboró offers thrilling hiking trails through diverse ecosystems, where you can spot unique wildlife. For adrenaline seekers, the nearby Chapare region features exhilarating white-water rafting experiences amidst stunning landscapes, perfect for adventure enthusiasts looking for an unforgettable experience.

Nightlife

In Santa Cruz, Bolivia, experience vibrant nightlife at Plaza 24 de Septiembre, filled with lively bars and clubs. Visit the trendy Equipetrol neighborhood for upscale lounges and dance the night away at popular venues like La Casa de la Cerveza and Club Level, where the energy is electric.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions in Santa Cruz

Santa Cruz, Bolivia, is perfect for city-themed and family vacations, offering rich cultural experiences. Explore popular attractions like the piazza, cathedral, and various landmarks that cater to diverse interests, including culture and outdoor activities. Don't miss out on discovering local gems and immersing yourself in the vibrant atmosphere of Santa Cruz for an unforgettable experience.

  • Plaza 24 de Septiembre: This vibrant square serves as the heart of Santa Cruz, where locals and visitors gather to enjoy cultural events, music, and lively street performances. Its lush gardens and historical significance make it a perfect spot to soak in the city's atmosphere and people-watch.
  • San Lorenzo Cathedral: A stunning example of colonial architecture, San Lorenzo Cathedral features intricate designs and a serene ambiance. Visitors can appreciate its artistic beauty and rich history while attending mass or exploring its peaceful surroundings.
  • Blacutt Square: Known for its unique excursions, Blacutt Square is a popular gathering place for locals and tourists alike. The square often hosts cultural fairs and events, offering a glimpse into the region's traditions and local crafts.

Best time to go to Santa Cruz

The best time to visit Santa Cruz can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Santa Cruz falls in October, when visitor numbers are slightly low and weather is mostly sunny with light rain. The coolest average temperature in Santa Cruz falls in June, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January78.3°F (25.7°C)Light RainMostly SunnySlightly HighAverage
February77.0°F (25.0°C)Light RainMostly CloudyAverageAverage
March76.5°F (24.7°C)Light RainMostly SunnyAverageSlightly High
April74.5°F (23.6°C)Light RainMostly SunnyAverageSlightly High
May70.2°F (21.2°C)Light RainMostly SunnySlightly LowAverage
June67.8°F (19.9°C)Light RainMostly SunnyAverageSlightly Low
July68.5°F (20.3°C)No RainMostly SunnySlightly HighAverage
August72.9°F (22.7°C)No RainSunnyAverageSlightly Low
September77.9°F (25.5°C)Light RainSunnySlightly HighSlightly High
October79.5°F (26.4°C)Light RainMostly SunnySlightly LowAverage
November79.3°F (26.3°C)Light RainMostly SunnyAverageSlightly Low
December78.4°F (25.8°C)Light RainMostly SunnySlightly LowAverage

Tips to save on your trip to Santa Cruz

  • Take advantage of package deals on Expedia and combine flights, hotels, or car rentals for a convenient and cost-effective trip to Santa Cruz.
  • Consider traveling during the off-peak season (typically June, August and November) for more affordable package holidays to Santa Cruz.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

Santa Cruz Essential Information

Language
Spanish
Currency
Bolivian bolivianos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Viru Viru Intl. Airport (VVI)
Max Temp Winter
80ºF
Max Temp Summer
90ºF
Top Sights
Santa Cruz Zoo, San Lorenzo Cathedral and Sacred Art Museum

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Frequently asked questions

How much does a Santa Cruz vacation package cost?
You'll find cheap prices from $921 on Expedia for your Santa Cruz break. However, a range of factors like the hotel choice, length of stay and season will determine how much your vacation to Santa Cruz costs.
What are the cheapest months to go to Santa Cruz?
If you'd like to score a cheap Santa Cruz vacation package, consider traveling in January, May and December. You'll typically find lower rates on hotels and airfares during these quieter months — ideal for a budget-friendly getaway.
How many days is enough for Santa Cruz?
Generally, a handful of days is enough to tick off the main sights during your Santa Cruz vacation. However, if you prefer to have more time to rest or take day trips, think about extending your trip.
Is it worth booking a vacation package to Santa Cruz?
Santa Cruz is a good vacation destination with attractions like Plaza 24 de Septiembre among the many things to keep you entertained. Whether you're heading away with the family or getting away with friends, a Santa Cruz vacation promises a good time for everyone.
How to find the best Santa Cruz package deals?
Use Expedia's filters to help you find some tempting Santa Cruz package deals. When you start your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or look for Santa Cruz package deals in the off-peak season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as early as possible.
Is it cheaper to book a Santa Cruz vacation as a package?
You can enjoy significant savings on your Santa Cruz escape by booking a personalized vacation package. Click on the "Package" heading, then enter your travel dates and destination to browse some great hotel prices and airfares. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Cruz?
If you're considering an impromptu Santa Cruz adventure, browse our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can find sensational deals on your flights and hotels by booking well in advance.
How to plan a trip to Santa Cruz?

  1. Choose your travel dates: What you plan to do in Santa Cruz and your preferred season can help you decide when to go.
  2. Calculate your budget: Ensure you have enough money to pay for everything from transportation and dining out to airfares and activities. Your hotel will likely be the largest expense during your trip to Santa Cruz.
  3. Discover Santa Cruz using Expedia's trip planning tool: Gain insights into the leading attractions and best stays for your trip to Santa Cruz. You can also save your favorite places, collaborate with family and friends and manage all your plans in one place.
  4. Decide how long to go for: Now that you're more familiar with Santa Cruz, you can work out the ideal length of your break. Create a rough plan and allocate enough time to cover everything you want to see.
  5. Bundle your accommodations and airfare: Once you've nailed down your dates and duration, lock in the ideal Santa Cruz vacation package for you.
  6. Book experiences or activities in advance: Whether it's a ticket to a major attraction or a day trip, you won't have to worry about missing out on the highlights of Santa Cruz. Find all the incredible things to do in Santa Cruz with our dedicated travel guide.

Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?
Your Santa Cruz break is meant to be an escape from your daily routine, not a source of money worries. So to give you a little more flexibility, we've teamed up with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any hidden costs or late payment fees to worry about.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.