Santa Cruz Vacations from $763

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Your Santa Cruz Vacation

With one of our vacation packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the program during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz vacation is just clicks away with Expedia.

The Latest Santa Cruz vacation packages

Price found within the past 48 hours. Click for updated prices.
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
Price was $834, price is now $763 per person
$763
per person
Dec 17 - Dec 21
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Santa Cruz (VVI)
9.6/10 Exceptional! (53 reviews)
The food was awesome!! Best fillet mignon I ever had in the year that I have been in Bolivia. The big issue that my wife and I had was the rooms are too small. You hardly have space to open your suitcase. So we cut our intended 5 night stay short and only stayed for 1 night. Another thing I noticed was staff moral seemed very low. Staff members didn't seem too happy to be working there.

Reviewed on Oct 5, 2025

Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra

4.5 out of 5
Price was $1,080, price is now $877 per person
$877
per person
Dec 17 - Dec 21
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Santa Cruz (VVI)
9.2/10 Wonderful! (78 reviews)
Excellent. Out of the way, not really walking distance to anything and not many taxis that pass by but the micro is easy to navigate and outside the door.very comfortable and excellent facilities and breakfast.

Reviewed on Feb 8, 2025

Hotel Cortez

Hotel Cortez

3.5 out of 5
Price was $967, price is now $847 per person
$847
per person
Dec 17 - Dec 21
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Santa Cruz (VVI)
9/10 Wonderful! (112 reviews)
Very nice and relaxing. The staff are very friendly and helpful. Very easy.

Reviewed on Apr 5, 2025

Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Price was $1,005, price is now $916 per person
$916
per person
Dec 17 - Dec 21
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Santa Cruz (VVI)
8.8/10 Excellent! (400 reviews)
Great Hotel, had a great time .

Reviewed on Jun 2, 2025

Hotel LP Equipetrol

Hotel LP Equipetrol

3.5 out of 5
Price was $842, price is now $769 per person
$769
per person
Dec 17 - Dec 21
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Santa Cruz (VVI)
8.2/10 Very Good! (199 reviews)
So, the mattress and pillows were not that comfortable, hard. No microwave and the sheets not the size of the bed, smaller. The treatment from the hotel personnel was good.

Reviewed on Feb 21, 2025

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Discover the most popular places to visit in Santa Cruz

Plaza 24 de Septiembre which includes heritage architecture and heritage elements as well as a large group of people

Plaza 24 de Septiembre

4.5/5(26 reviews)

The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.

Plaza 24 de Septiembre
San Lorenzo Cathedral which includes heritage elements, heritage architecture and a church or cathedral

San Lorenzo Cathedral

4.5/5(15 reviews)

One of the most iconic landmarks in Santa Cruz is the city’s mighty cathedral, which houses a museum displaying important artwork.

San Lorenzo Cathedral

Ventura Mall

4.5/5(28 reviews)

During your visit to Santa Cruz, you can find the perfect gifts to bring home at Ventura Mall. Make some time to visit the cathedral while you're in the area.

Ventura Mall

Santa Cruz Hotel Deals

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA, Santa Cruz
$38 nightly
The price is $38 total per night from Nov 11 to Nov 12
$38 total
Nov 11 - Nov 12
9.4/10 Exceptional! (61 reviews)
"The"

Reviewed on Jul 28, 2025

Ibis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
$118 nightly
The price is $118 total per night from Oct 18 to Oct 19
$118 total
Oct 18 - Oct 19
8.8/10 Excellent! (331 reviews)
"Hotel was excellent. Staff excellent, check in good and bar resturant really good. room was good and clean"

Reviewed on Oct 3, 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23, At Calle Las Ramblas, Santa Cruz, Santa Cruz
$103 nightly
The price is $103 total per night from Oct 17 to Oct 18
$103 total
Oct 17 - Oct 18
8.8/10 Excellent! (199 reviews)
"Very comfortable"

Reviewed on Sep 25, 2025

Marriott Santa Cruz de la Sierra Hotel
See all 280 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santa Cruz Essential Information

Language
Spanish
Currency
Bolivian bolivianos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Viru Viru Intl. Airport (VVI)
Max Temp Winter
80ºF
Max Temp Summer
90ºF
Top Sights
Santa Cruz Zoo, San Lorenzo Cathedral and Sacred Art Museum

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Frequently asked questions

How much does a Santa Cruz vacation package cost?
You'll find cheap prices from $763 on Expedia for your Santa Cruz break. However, a range of factors like the hotel choice, length of stay and season will determine how much your vacation to Santa Cruz costs.
What are the cheapest months to go to Santa Cruz?
If you'd like to score a cheap Santa Cruz vacation package, consider traveling in January, May and December. You'll typically find lower rates on hotels and airfares during these quieter months — ideal for a budget-friendly getaway.
How many days is enough for Santa Cruz?
Generally, a handful of days is enough to tick off the main sights during your Santa Cruz vacation. However, if you prefer to have more time to rest or take day trips, think about extending your trip.
Is it worth booking a vacation package to Santa Cruz?
Santa Cruz is a good vacation destination with attractions like Plaza 24 de Septiembre among the many things to keep you entertained. Whether you're heading away with the family or getting away with friends, a Santa Cruz vacation promises a good time for everyone.
How to find the best Santa Cruz package deals?
Use Expedia's filters to help you find some tempting Santa Cruz package deals. When you start your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or look for Santa Cruz package deals in the off-peak season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as early as possible.
Is it cheaper to book a Santa Cruz vacation as a package?
You can enjoy significant savings on your Santa Cruz escape by booking a personalized vacation package. Click on the "Package" heading, then enter your travel dates and destination to browse some great hotel prices and airfares. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Cruz?
If you're considering an impromptu Santa Cruz adventure, browse our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can find sensational deals on your flights and hotels by booking well in advance.
How to plan a trip to Santa Cruz?

  1. Choose your travel dates: What you plan to do in Santa Cruz and your preferred season can help you decide when to go.
  2. Calculate your budget: Ensure you have enough money to pay for everything from transportation and dining out to airfares and activities. Your hotel will likely be the largest expense during your trip to Santa Cruz.
  3. Discover Santa Cruz using Expedia's trip planning tool: Gain insights into the leading attractions and best stays for your trip to Santa Cruz. You can also save your favorite places, collaborate with family and friends and manage all your plans in one place.
  4. Decide how long to go for: Now that you're more familiar with Santa Cruz, you can work out the ideal length of your break. Create a rough plan and allocate enough time to cover everything you want to see.
  5. Bundle your accommodations and airfare: Once you've nailed down your dates and duration, lock in the ideal Santa Cruz vacation package for you.
  6. Book experiences or activities in advance: Whether it's a ticket to a major attraction or a day trip, you won't have to worry about missing out on the highlights of Santa Cruz. Find all the incredible things to do in Santa Cruz with our dedicated travel guide.

Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?
Your Santa Cruz break is meant to be an escape from your daily routine, not a source of money worries. So to give you a little more flexibility, we've teamed up with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any hidden costs or late payment fees to worry about.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.